Jose Antonio: Educator of the Year

At this year's 32nd annual NSCA conference, ISSN's CEO, Jose Antonio, PhD, CSCS, FNSCA was named Educator of the Year.

Dr. Antonio (on the left in this photo with Dr. Lee Brown) earned this honor for his contributions to teaching and the clinical application in the field of strength training and conditioning. In the words of Robert Jursnick, NSCA's Executive Director, "Jose's well-earned award and his contributions shape NSCA into what it is today."

If you missed this year's NSCA meeting, count on attending next year. I know podcasts, webinars and the like are the current trend for obtaining CEUs but, foregoing conferences means you miss out on networking and you miss out on meeting many people who are truly inspirations to this field.

The NSCA conference gives you access to the people who shape the field of strength and conditioning, those who conduct the research studies we base our programs on and the top trainers and strength coaches worldwide. It's truly an honor and a privilege to know both Jose and Lee Brown, learn from their experiences and listen to their ideas for the future.

Whey still best

This study was designed to compare the acute response of mixed muscle protein synthesis (MPS) to rapidly (i.e., whey hydrolysate and soy) and slowly (i.e., micellar casein) digested proteins both at rest and after resistance exercise. Three groups of healthy young men (n=6 per group) performed a bout of unilateral leg resistance exercise followed by the consumption of a drink containing an equivalent content of essential amino acids (10g) as either whey hydrolysate, micellar casein, or soy protein isolate. Mixed muscle protein synthesis (MPS) was determined by a primed constant infusion of L-[ring-(13)C6]phenylalanine. Ingestion of whey protein resulted in a larger increase in blood essential amino acid, branched-chain amino acid, and leucine concentrations than either casein or soy (P<0.05). Mixed MPS at rest (determined in the non-exercised leg) was higher with ingestion of faster proteins (whey=0.091+/-0.015, soy=0.078+/-0.014, casein=0.047+/-0.008 %(.)h(-1);); MPS after consumption of whey was ~93% greater than casein (P<0.01) and ~18% greater than soy (P=0.067). A similar result was observed after exercise (whey>soy>casein); MPS following whey consumption was ~122% greater than casein (P<0.01) and 31% greater than soy (P<0.05). MPS was also greater with soy consumption at rest (64%) and following resistance exercise (69%) compared to casein (both p<0.01). We conclude that the feeding-induced simulation of MPS in young men is greater after whey hydrolysate or soy protein consumption than casein both at rest and after resistance exercise; moreover, despite both being fast proteins whey hydrolysate stimulated MPS to a greater degree than soy after resistance exercise. These differences may be related to how quickly the proteins are digested (i.e., fast vs. slow) or possibly to small differences in leucine content of each protein. Key words: hypertrophy, muscle mass, weightlifting.

J Appl Physiol. 2009 Jul 9. [Epub ahead of print]
Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men.
Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM.
McMaster University.

Microencapsulated foods as a functional delivery vehicle for omega-3 fatty acids: a pilot study

It is well established that the ingestion of the omega-3 (N3) fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) positively benefit a variety of health indices. Despite these benefits the actual intake of fish derived N3 is relatively small in the United States. The primary aim of our study was to examine a technology capable of delivering omega-3 fatty acids in common foods via microencapsulation (MicroN3) in young, healthy, active participants who are at low risk for cardiovascular disease. Accordingly, we randomized 20 participants (25.4 +/- 6.2 y; 73.4 +/- 5.1 kg) to receive the double blind delivery of a placebo-matched breakfast meal (~2093 kJ) containing MicroN3 (450-550 mg EPA/DHA) during a 2-week pilot trial. Overall, we observed no differences in overall dietary macronutrient intake other than the N3 delivery during our treatment regimen. Post-test ANOVA analysis showed a significant elevation in mean (SE) plasma DHA (91.18 +/- 9.3 vs. 125.58 +/- 11.3 umol/L; P<0.05) and a reduction in triacylglycerols (89.89 +/- 12.8 vs. 80.78 +/- 10.4 mg/dL; P<0.05) accompanying the MicroN3 treatment that was significantly different from placebo (P < 0.05). In post study interviews, participants reported that the ingested food was well-tolerated, contained no fish taste, odor or gastrointestinal distress accompanying treatment. The use of MicroN3 foods provides a novel delivery system for the delivery of essential fatty acids. Our study demonstrates that MicroN3 foods promote the absorption of essential N3, demonstrate bioactivity within 2 weeks of ingestion and are well tolerated in young, active participants who are at low risk for cardiovascular disease.

White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes.

Source: Nutr Metab (Lond). 2009 May 1;6(1):20. [Epub ahead of print]

ABSTRACT: BACKGROUND: The dramatic increase in obesity-related diseases emphasizes the need to elucidate the cellular and molecular mechanisms underlying fat metabolism. To investigate how natural substances influence lipolysis and adipogenesis, we determined the effects of White Tea extract on cultured human subcutaneous preadipocytes and adipocytes. METHODS: For our in vitro studies we used a White Tea extract solution that contained polyphenols and methylxanthines. Utilizing cultured human preadipocytes we investigated White Tea extract solution-induced inhibition of triglyceride incorporation during adipogenesis and possible effects on cell viability. In vitro studies on human adipocytes were performed aiming to elucidate the efficacy of White Tea extract solution to stimulate lipolytic activity. To characterize White Tea extract solution-mediated effects on a molecular level, we analyzed gene expression of essential adipogenesis-related transcription factors by qRT-PCR and determined the expression of the transcription factor ADD1/SREBP-1c on the protein level utilizing immunofluorescence analysis. RESULTS: Our data show that incubation of preadipocytes with White Tea extract solution significantly decreased triglyceride incorporation during adipogenesis in a dose- dependent manner (n = 10) without affecting cell viability (n = 10). These effects were, at least in part, mediated by EGCG (n = 10, 50 muM). In addition, White Tea extract solution also stimulated lipolytic activity in adipocytes (n = 7). Differentiating preadipocytes cultivated in the presence of 0.5% White Tea extract solution showed a decrease in PPARgamma, ADD1/SREBP-1c, C/EBPalpha and C/EBPdelta mRNA levels. Moreover, the expression of the transcription factor ADD1/SREBP-1c was not only decreased on the mRNA but also on the protein level. CONCLUSIONS: White Tea extract is a natural source that effectively inhibits adipogenesis and stimulates lipolysis-activity. Therefore, it can be utilized to modulate different levels of the adipocyte life cycle.

Cereal with milk is better than sugar-filled sports drinks

Posted originally here: http://www.examiner.com/x-10474-Newark-Mens-Health-Examiner~y2009m5d21-Eat-some-crunch-berries-before-the-gym

In college, I once watched a kid eat two hotdogs with ketchup and a bowl of Lucky Charms for dinner. I was in awe. But maybe the gross stoner was onto something.

Because new findings in the Journal of the International Society of Sports Nutrition claim eating a bowl of cereal and milk works better before a workout than sports drinks.

For the study, scientists had 12 trained cyclists, 8 male and 4 female, go through a typical exercise routine, a brief warm-up followed by two hours of peddling at a comfortable pace.

Researchers say a bowl of whole grain cereal and milk recharged muscles just as good as sports drinks, calling it a better option for amateur athletes than pricey drinks, but here’s the catch.

The study was sponsored by the General Mills Bell Institute of Health and Nutrition. Clearly, there is a not-so hidden agenda here. A lot like a recent resport by the Wrigley Science Institute, which claims chewing gum helps control appetite and weight-gain.

Now, if I’m feeling picky before Yoga I grab a banana. Not cereal. Then again, I’m lactose intolerant. So having milk then squatting would not be a good idea.

GPLC improves performance!

An interesting study which shows that Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. http://www.jissn.com/content/6/1/9/abstract

Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind tria

E Smith , Ashley A Walter , Jennifer L Graef , Kristina L Kendall , Jordan R Moon , Christopher M Lockwood , David H Fakuda , Travis W Beck , Joel T Cramer and Jeffrey R Stout
Journal of the International Society of Sports Nutrition 2009, 6:5doi:10.1186/1550-2783-6-5
Published: 11 February 2009
Abstract: Intermittent bouts of high-intensity exercise result in diminished stores of energy substrates, followed by an accumulation of metabolites, promoting chronic physiological adaptations. In addition,
-alanine has been accepted has an effective physiological hydrogen ion (H+) buffer. Concurrent high-intensity interval training (HIIT) and
-alanine supplementation may result in greater adaptations than HIIT alone. The purpose of the current study was to evaluate the effects of combining
-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in recreationally active college-aged men. Methods. Forty-six men (Age: 22.2 ± 2.7 yrs; Ht: 178.1 ± 7.4 cm; Wt: 78.7 ± 11.9; VO2peak: 3.3 ± 0.59 l·min-1) were assessed for peak O2 utilization (VO2peak), time to fatigue (VO2TTE), ventilatory threshold (VT), and total work done at 110% of pre-training VO2peak (TWD). In a double-blind fashion, all subjects were randomly assigned into one either a placebo (PL – 16.5g dextrose powder per packet; n=18) or
-alanine (BA – 1.5 g
-alanine plus 15 g dextrose powder per packet; n=18) group. All subjects supplemented four times per day (total of 6g/day) for the first 21-days, followed by two times per day (3g/day) for the subsequent 21 days, and engaged in a total of six weeks of HIIT training consisting of 5-6 bouts of a 2:1 minute cycling work to rest ratio. Results. Significant improvements in VO2peak, VO2TTE, and TWD after three weeks of training were displayed (p<0.05). Increases in VO2peak, VO2TTE, TWD and lean body mass were only significant for the BA group after the second three weeks of training. Conclusions. The use of HIIT to induce significant aerobic improvements is effective and efficient. Chronic BA supplementation may further enhance HIIT, improving endurance performance and lean body mass.
Discussion:
-alanine supplementation appeared to have a greater influence on VO2peak and VO2TTE, resulting in a significant (p<0.05) increase during the second three weeks of training, while no change occurred in placebo group. In addition, TWD significantly (p<0.05) increased during the last three weeks by 32% and 18% for the
-alanine and Placebo groups, respectively. Improvements in VT were also reported for both training groups, however the placebo group demonstrated significant improvements during the last three week training phase (Table 1). Lastly, the present study also identified a significant change in lean body mass for the
-alanine supplementing group after three weeks, with no change in the placebo group.
My Take on it.I would like to see the study repeated on trained subjects to see if that affects the results. Additionally I would like to see the training intensities and volumes to be equal between groups. Although not statistically significant, it was stated that the BA group trained consistently at higher workloads and durations than the placebo groups and this could certainly effect body composition as well as other physiological responses.Nevertheless, I shall be trying this supplement on myself and then may suggest it to my clients!

Creatine Ethyl Ester is not superior to Creatine Monohydrate

In a study out of Darryn Willoughby's lab, they compared CEE vs cretine moonhydrate. The data speaks for itself.

This study examined how a seven-week supplementation regimen combined with resistance training affected body composition, muscle mass, muscle strength and power, serum and muscle creatine levels, and serum creatinine levels in 30 non-resistance-trained males. In a double-blind manner, participants were randomly assigned to a maltodextrose placebo (PLA), creatine monohydrate (CRT), or creatine ethyl ester (CEE) group. The supplements were orally ingested at a dose of 0.30 g/kg fat-free body mass (approximately 20 g/day) for five days followed by ingestion at 0.075 g/kg fat free mass (approximately 5 g/day) for 42 days. Results showed significantly higher serum creatine concentrations in PLA (p = 0.007) and CRT (p = 0.005) compared to CEE. Serum creatinine was greater in CEE compared to the PLA (p = 0.001) and CRT (p = 0.001) and increased at days 6, 27, and 48. Total muscle creatine content was significantly higher in CRT (p = 0.026) and CEE (p = 0.041) compared to PLA, with no differences between CRT and CEE. Significant changes over time were observed for body composition, body water, muscle strength and power variables, but no significant differences were observed between groups. In conclusion, when compared to creatine monohydrate, creatine ethyl ester was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power. Therefore, the improvements in these variables can most likely be attributed to the training protocol itself, rather than the supplementation regimen.

High School Kids Suspended for POSSESSION of Creatine

Comment: Yes, there are complete idiots out there. Nothing really left to say about this doozy.
http://www.vindy.com/news/2009/feb/13/struthers-8212-lennard-burke-jr-a-sophomore/
Published: Friday, February 13, 2009

By William k. Alcorn

STRUTHERS — Lennard Burke Jr., a sophomore at Struthers High School, was still waiting Thursday for the results of his appeal of a 10-day suspension for possessing a muscle-building supplement containing creatine in school.

The 15-year-old’s appeal Wednesday before Schools Superintendent Robert Rostan lasted about five minutes, during which time he and his father, Lennard Sr., presented his case.

Burke Sr. said Rostan did not make an immediate decision and said he would mail his decision to the family.

Burke Jr. was suspended beginning Feb. 4, and could be expelled from school, for possession of the supplement that his father says is neither a prescription nor an over-the-counter medicine.

“We don’t have a problem with the school setting policy. We just don’t think creatine was a banned substance when my son was suspended,” Burke Sr. said.

Burke Sr. said that if the suspension escalates into expulsion he would also appeal that decision.

In a related matter, Burke Sr. said he and his wife, Gina, plan to pursue complaints filed with the Ohio Department of Education against Joseph Fuline, associate high school principal, and Mary Ann Meadows, high school principal.

Burke said the complaints are the result of a confrontation between him and his wife and the school officials the day of Burke Jr.’s suspension. Burke said he does not believe he and his wife were treated professionally.

Burke Sr. said his son is a student-athlete. It’s not all about football and weight lifting. He just wants to get back to school and be a student.

alcorn@vindy.com

Dietary protein safety and resistance exercise: what do we really know?

Lonnie M. Lowery and Lorena Devia. Dietary protein safety and resistance exercise: what do we really know? J Int Soc Sports Nutr. 2009 Jan 12;6:3.

Abstract: Resistance trainers continue to receive mixed messages about the safety of purposely seeking ample dietary protein in their quest for stimulating protein synthesis, improving performance, or maintaining health. Despite protein's lay popularity and the routinely high intakes exhibited by strength athletes, liberal and purposeful protein consumption is often maligned by "experts". University textbooks, instructors, and various forms of literature from personal training groups and athletic organizations continue to use dissuasive language surrounding dietary protein. Due to the widely known health benefits of dietary protein and a growing body of evidence on its safety profile, this is unfortunate. In response, researchers have critiqued unfounded educational messages. As a recent summarizing example, the International Society of Sports Nutrition (ISSN) Position Stand: Protein and Exercise reviewed general literature on renal and bone health. The concluding remark that "Concerns that protein intake within this range [1.4 – 2.0 g/kg body weight per day] is unhealthy are unfounded in healthy, exercising individuals." was based largely upon data from non-athletes due to "a lack of scientific evidence". Future studies were deemed necessary. This assessment is not unique in the scientific literature. Investigators continue to cite controversy, debate, and the lack of direct evidence that allows it. This review discusses the few existing safety studies done specific to athletes and calls for protein research specific to resistance trainers. Population-specific, long term data will be necessary for effective education in dietetics textbooks and from sports governing bodies.



While reading along with this review article it occurred to me just how unsure scientists in Ex Sci are of just how important protein intake is to athletes (particularly strength athletes). These studies that have been conducted are mostly on sedentary individuals which has its place of course however it is very hard to generalize and assume that everyone's body (trained or untrained) will synthesise excess protein similarly. This review also mentions ISSN's position on protein consumption and how it is unfounded as to how much protein is necessary for athletes and just exactly how much is too much. Many claims are made you can see them in all types of media without scientific support. If excessive protein intake is so dangerous than why isn't the number of bodybuilders/powerlifters death's due to renal disease or suffering from osteoporosis (since excessive protein consumtion is believed to create bone catabolism) at a preamature age? Also, is it possible that maybe its not just excessive protein consumption but perhaps it also deals with the "type" of protein consumed that have the so called detrimental effects on the body? Even though there aren't many studies that show excess protein is good or bad for athletes. According to Wolff's Law: The body will conform and adapt to the directions and stresses it is habitually exposed to. Now this law may apply to bone specifically, however, it is my thought that your body is always in survival mode. Therefore, any stress you put your body through habitually it will try to adapt and find better ways accomodate this contiuous stress. Also, I heard this from someone somewhere, if you overload your system with protein won't you force yourself into gluconeogenisis in which your body will begin using the excess protein (amino acids) for energy? I'm not sure, anyone got a response?

Abstract:Examination of a pre-exercise, high energy supplement on exercise performance

Background
The purpose of this study was to examine the effect of a pre-exercise high energy drink on reaction time and anaerobic power in competitive strength/power athletes. In addition, the effect of the pre-exercise drink on subjective feelings of energy, fatigue, alertness and focus was also explored.
Methods
Twelve male strength/power athletes (21.1 ± 1.3 y; 179.8 ± 7.1 cm; 88.6 ± 12.1 kg; 17.6 ± 3.3% body fat) underwent two testing sessions administered in a randomized and double-blind fashion. During each session, subjects reported to the Human Performance Laboratory and were provided with either 120 ml of a high energy drink (SUP), commercially marketed as Redline Extreme® or 120 ml of a placebo (PL) that was similar in taste and appearance but contained no active ingredients. Following consumption of the supplement or placebo subjects rested quietly for 10-minutes prior to completing a survey and commencing exercise. The survey consisted of 4 questions asking each subject to describe their feelings of energy, fatigue, alertness and focus for that moment. Following the completion of the questionnaire subjects performed a 2-minute quickness and reaction test on the Makoto testing device (Makoto USA, Centennial CO) and a 20-second Wingate Anaerobic Power test. Following a 10-minute rest subjects repeated the testing sequence and after a similar rest period a third and final testing sequence was performed. The Makoto testing device consisted of subjects reacting to both a visual and auditory stimulus and striking one out of 30 potential targets on three towers.
Results
Significant difference in reaction performance was seen between SUP and PL in both average number of targets struck (55.8 ± 7.4 versus 51.9 ± 7.4, respectively) and percent of targets struck (71.9 ± 10.5% versus 66.8 ± 10.9%, respectively). No significant differences between trials were seen in any anaerobic power measure. Subjective feelings of energy (3.5 ± 0.5 versus 3.1 ± 0.5) and focus (3.8 ± 0.5 versus 3.3 ± 0.7) were significantly higher during SUP compared to PL, respectively. In addition, a trend towards an increase in average alertness (p = 0.06) was seen in SUP compared to P.
Conclusion
Results indicate a significant increase in reaction performance, with no effect on anaerobic power performance. In addition, ingestion of this supplement significantly improves subjective feelings of focus and energy in male strength/power athletes.

My take:
I always see Redline products being marketed as a weight management supplement. It was good to see a study that tested reaction time, anaerobic power, and alertness after ingesting Redline. Unfortunately for myself, and a great percentage of the individuals that work out at the same gym, Redline extreme doesn't seem to offer any added benefit towards anaerobic power. One positive result people can take from this study, is on those days where you are physically and mentally fatigued Redline extreme may offer a solution to your alertness and reaction times to help power through your workout.
One problem I had with the design is 10 minutes after ingestion the subjects completed a four question survey then began their physical tests. The authors did not make it clear how long the survey took, but I am assuming four questions did not take too long. So overall each trial may have taken 45 minutes to an hour max to complete (if my math is correct) and I was under the impression that caffeine and other stimulants can take 15-45 minutes to start "kicking in." A possible future study could take that into account.

Meltdown: Thermogenic Effect of an acute ingestion of a weight loss supplement.

Abstract
The purpose of this study was to examine the acute effects of a weight loss supplement on resting oxygen uptake (VO2), respiratory quotient (RQ), caloric expenditure (kcal), heart rate (HR), and blood pressure (BP) in healthy and physically active individuals.
Methods
Ten subjects (5 male, 5 female; 20.2 ± 1.2 y; 172.2 ± 8.9 cm; 71.5 ± 17.2 kg; 17.3 ± 2.6% body fat) underwent two testing sessions administered in a randomized and double-blind fashion. During each session, subjects reported to the Human Performance Laboratory after at least 3-h post-absorptive state and were provided either 3 capsules of the weight loss supplement (SUP), commercially marketed as Meltdown® or 3 capsules of a placebo (P). Subjects then rested in a semi-recumbent position for three hours. VO2 and HR were determined every 5 min during the first 30 min and every 10 min during the next 150 min. BP was determined every 15 min during the first 30 min and every 30 min thereafter. The profile of mood states was assessed every 30 min.
Results
Area under the curve analysis revealed a significant 28.9% difference in VO2 between SUP and P for the three hour study period. In addition, a significant difference in energy expenditure was also seen between SUP (1.28 ± 0.33 kcal·min-1) and P (1.00 ± 0.32 kcal·min-1). A trend (p = 0.06) towards a greater utilization of stored fat as an energy source was also demonstrated (0.78 ± 0.23 kcal·min-1 and 0.50 ± 0.38 kcal·min-1 in P and SUP, respectively). Significant elevations in HR were seen during hours two and three of the study, and significantly higher average systolic BP was observed between SUP (118.0 ± 7.3 mmHg) and P (111.4 ± 8.2 mmHg). No significant differences were seen in diastolic blood pressure at any time point. Significant increases in tension and confusion were seen in SUP.
Conclusion
Results indicate a significant increase in energy expenditure in young, healthy individuals following an acute ingestion of a weight loss supplement. In addition, ingestion of this supplement appears to modify mood and elevate HR and systolic BP following ingestion
Reference
Thermogenic effect of an acute ingestion of a weight loss supplement
Jay R Hoffman , Jie Kang , Nicholas A Ratamess , Stefanie L Rashti , Christopher P Tranchina and Avery D Faigenbaum
Department of Health and Exercise Science, The College of New Jersey, PO Box 7718, Ewing, New Jersey 08628, USA

My take on it?
I had always thought that Ephedra was a nifty weight loss supplement so I wondered how long it would be before someone tried to do an end run around the FDA ban on it.
The supplement studied here (Meltdown) contains synephrine, which certainly sounds like it is related to ephedrine . . . but the authors don't make that clear.
Whilst more studies will no doubt be done on this one, I think the side effects of increased anxiety and confusion may be problematic, not to mention the increased Systolic BP. Additionally there seems to be an increase in vasoconstriction (hence the increased SBP), that could be problematic if this supplement were used in conjunction with exercise in the heat.

Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle.

Saengsirisuwan V, Perez FR, Kinnick TR, Henriksen EJ.

Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, College of Medicine, Tucson, Arizona 85721-0093, USA.

We have recently demonstrated (Saengsirisuwan V, Kinnick TR, Schmit MB, and Henriksen EJ, J Appl Physiol 91: 145-153, 2001) that exercise training (ET) and the antioxidant R-(+)-alpha-lipoic acid (R-ALA) interact in an additive fashion to improve insulin action in insulin-resistant obese Zucker (fa/fa) rats. The purpose of the present study was to assess the interactions of ET and R-ALA on insulin action and oxidative stress in a model of normal insulin sensitivity, the lean Zucker (fa/-) rat. For 6 wk, animals either remained sedentary, received R-ALA (30 mg. kg body wt(-1). day(-1)), performed ET (treadmill running), or underwent both R-ALA treatment and ET. ET alone or in combination with R-ALA significantly increased peak oxygen consumption (28-31%) and maximum run time (52-63%). During an oral glucose tolerance test, ET alone or in combination with R-ALA resulted in a significant lowering of the glucose response (17-36%) at 15 min relative to R-ALA alone and of the insulin response (19-36%) at 15 min compared with sedentary controls. Insulin-mediated glucose transport activity was increased by ET alone in isolated epitrochlearis (30%) and soleus (50%) muscles, and this was associated with increased GLUT-4 protein levels. Insulin action was not improved by R-ALA alone, and ET-associated improvements in these variables were not further enhanced with combined ET and R-ALA. Although ET and R-ALA caused reductions in soleus protein carbonyls (an index of oxidative stress), these alterations were not significantly correlated with insulin-mediated soleus glucose transport. These results indicate that the beneficial interactive effects of ET and R-ALA on skeletal muscle insulin action observed previously in insulin-resistant obese Zucker rats are not apparent in insulin-sensitive lean Zucker rats.

POST BY: Kevin Jones

Comments: First off, I'm not sure if I am doing this correctly. Please let me know if this is OK. Second, I wanted to post an article about ALA but I could not find any relevant studies on humans and glucose uptake. All I could find was studies on rats...

But after reading a few of these reports on ALA, it makes me wonder if I am just wasting my time and money on ALA supplements. From what I've gathered, ALA is only effective in insulin resistant obese individuals. I was under the impression that ALA mimicked insulin and helped increase glucose uptake, therefore increasing glycogen stores. But I am neither diabetic nor obese, so does the ALA do anything at all for me? I also believed that it is a powerful free radical scavenger and would be smart to use after exercise as an anti-oxidant to protect against all the metabolic by-products created during the workout.

FTC Proposes Revisions To Guidelines for Advertising Endorsements

The Federal Trade Commission ("FTC") has requested comment on amendments to its Guides Concerning the Use of Endorsements and Testimonials in Advertising ("Guides"). These Guides govern the use of consumer and expert endorsements and testimonials in advertising — including viral advertising occurring through blogs and other Internet-based endorsement programs. Although the Guides are not binding, they explain how the FTC interprets Section 5 of the FTC Act’s prohibition on unfair or deceptive acts or practices. Consequently, the FTC could bring a Section 5 enforcement action based on practices that are inconsistent with the Guides.

As background, the FTC has not changed its Guides since they were released in 1980. In January 2007, the Commission released two studies it had commissioned on testimonials and issued a broad invitation for comments on the continued importance and appropriateness of the Guides. Twenty-two comments were submitted. Based on this feedback, the Commission is now proposing extensive revisions to the 1980 Guides. The changes to the Guides include:

declaring that both advertisers and endorsers are legally responsible for false or unsubstantiated statements made in endorsements, or failing to disclose material relationships;
eliminating the safe harbor formerly provided by "results not typical" language in consumer testimonials;
expanding the obligation of experts and celebrities to disclose certain contractual relationships (for instance, when speaking on talk shows); and
suggesting potentially sweeping liability for advertisers who encourage blogging about and viral marketing of their products.

JISSN Announces New Editors-in-Chief

The JISSN announces that Jose Antonio, Ph.D. and Douglas Kalman, R.D., Ph.D. will take over the helm of Editor in Chief for the Journal of the International Society of Sports Nutrition. Under the previous leadership of Dr. Richard Kreider, of Texas A & M, the JISSN has grown to be the leading source of scientic information in the sports nutrition and supplements category. Click here to read the latest studies in the JISSN.

Milk Your Workout for all It’s Worth—5 Wheys Low-Fat Dairy is a Nutrient Powerhouse

Is your body getting what it needs after a workout? So many sports and health products are released every year; each one boasting superior benefits for workout recovery. Neon-colored drinks are posed as the best source of hydration, while formulations designed to emulate human milk are advertised as optimal muscle-building fuel, with little or no research to support the claims. If your blender is simply building clutter, and doing little for your muscles, look no further than cooler or your local grocer or convenience store for a convenient, effective post workout. Plain old non-fat or low-fat milk is a perfect post-workout recovery drink. So what are some traits of a good workout supplement?

1. Provides carbohydrates in the form of sugar

2. Good source of high quality protein, but is also low in fat

3. Protein content also has branched-chain amino acids

4. Contains liquid and electrolytes

5. Inexpensive and convenient

1. Provides carbohydrates in the form of sugar

After a workout, the body needs recovery food to completely benefit from the exercise. Carbohydrates are important after a workout for a few reasons. First of all, they help to maintain blood sugar, especially for people who are likely to experience hypoglycemic (low blood sugar) symptoms; Type 2 diabetics fall into this category. Also, sugar is a potent stimulator of insulin. Following a workout, insulin binds to recpetors on the muscle and sends a“signal” that it is time to make protein. An insulin spike right after a workout tells the genes for making muscle proteins to become activated.

Finally, sugar is a good source of carbohydrate for the quick replacement of glycogen stores. This is especially important for athletes (of any age and competition level) who will be playing in a tournament or several matches back to back. Athletes “hit the wall” when muscle glycogen is depleted; the sooner carbohydrate makes it to your muscles, the better. Skim milk contains the two-unit sugar lactose.

Also, sweetened low-fat milk products are also good to have after a workout. One study, conducted by Karp and his colleagues, compared low-fat chocolate milk to either a traditional hydration drink or another carbohydrate-containing beverage in between two hard endurance workouts. The athletes who got the chocolate milk were able to exercise longer in the second bout. In addition to chocolate milk, low-fat ice cream or low-fat yogurt are also good choices.

2. Good source of high quality protein, but is also low in fat

Once the muscles get the signal to increase protein synthesis, they need a steady stream of building blocks, or amino acids, to complete the process. Amino acids are obtained from protein in food. Milk is an especially good source of protein because it contains both quick-absorbing whey and slower-absorbing casein. Both of these protein types are shown to increase protein synthesis after a workout; however, some researchers think that the muscle-building benefits of each protein are maximized when the two are taken together. Unfortunately, many high quality protein sources are in solid form and also packaged with a lot of extra fat. Fat slows the rate at which food is emptied from the stomach into the small intestine, so having too much fat after a workout slows the adsorption of much-needed sugars and amino acids into the blood. This is why high-fat post-workout drink may not be a good choice. Low-fat dairy is one of the few natural, high-quality protein, low-fat post workout options.

3. Protein content also has branched-chain amino acids

Not all amino acids are created equal. Some cannot be made in the body and are considered “essential.” Branched-chain amino acids (BCAA) and the BCAA leucine, in particular, are special for a couple of reasons. First of all, the muscle prefers to use BCAA as fuel during a workout; the body will break down your own muscle mass to get them if your supply if insufficient, since all BCAA are essential amino acids. Also, the BCAA leucine, like insulin, tells the muscles to make more structural proteins, so leucine is both a nutrient and a “signal.” Low-fat milk is a great source of leucine; specifically, milk contains about 0.8g of leucine per 8oz (240mL) cup. Typically, sports nutrition experts recommend about 1.5-2 grams of leucine following a workout; therefore, 2 cups of fat-free milk would put you the ball park by providing 1.6 grams of muscle-building leucine.

4. Contains liquid and electrolytes

Until recently, it was assumed that the best post workout hydration source is an fruity electrolyte drink. However, a recent article published in the British Journal of Nutrition found that low-fat milk promotes hydration after exercise better than either commonly used sports drink or water.

5. Inexpensive and convenient

Last, but certainly not least, you shouldn’t have to go out of your way to give your body what it needs after a hard day and an even harder workout. Low-fat milk, ice cream and yogurts are everywhere! In summary, according to Karen Kafer, RD, National Dairy Council, “[Milk is a] nutrient-rich package…for athletes: protein, carbohydrates, fluid and electrolytes, and vitamins and minerals. The vitamin and mineral package in milk includes calcium, phosphorus, vitamin D, vitamin A, riboflavin, vitamin B12, niacin and potassium. Together these help with strong bones, convert energy to fuel working muscles and maintain fluid and mineral balance."

Jean offers nutrition coaching for weight loss, muscle gain, or any of your personal goals at her office in the Alico building in downtown Waco, TX. She also offers personal training services at Ironhorse gym on the corner of Franklin and 17th, which is also very convenient to downtown. Contact information can be found on her personal website.

BCAAs ameliorate fatigue due to sailing

Eur J Appl Physiol. 2008 Nov;104(5):787-94. Epub 2008 Aug 13. Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race. Portier H, Chatard JC, Filaire E, Jaunet-Devienne MF, Robert A, Guezennec CY. AMAPP EA 4248, Université d'Orléans, 2 allée du château, Orléans, France. hugues.portier@univ-orleans.fr

The aim of the present study was to investigate the effect of protein diets, rich in branched chain amino acids (BCAA) on perceived exertion, mental and physical performance during an offshore sailing race that lasted 32 h. Twelve sailors were randomly allocated into one of two groups [Control (CON) and BCAA: n = 6/group]. The BCAA group consumed a standard diet of 11.2 MJ day(-1) (58% carbohydrate, 30% fat, 12% Protein) along with a high-protein supplement of 1.7 MJ day(-1) (40% carbohydrate, 35% protein, 25% fat) and 1.7 MJ day(-1) composed of 50% valine, 35% leucine, and 15% isoleucine. CON was given a standard diet of 14.5 MJ day(-1) (58% carbohydrate, 30% fat and 12% protein). During the race, heart rate was monitored. Subjects self-evaluated their feeling of fatigue every 3 h, and 12 samples of saliva from each subject were collected to perform cortisol assays. Before and after the race a vertical jump and a handgrip test were performed, and mental performance was evaluated with a standardized battery of tests. A significant increase in the feeling of fatigue was noted on the second day (D2) of race in both groups; the increase was higher in CON (P < 0.05). For both groups, salivary cortisol concentration followed a nycthemeral rhythm, with an alteration during the race as evidenced by high midnight cortisol levels between D1 and D2, and significantly decreased cortisol levels observed on D2 (P < 0.05). There was no change in physical performance at the end of the race in both groups. As a significant decrease (P < 0.05) in short-term memory performance was observed only in the CON group. These data indicate that an offshore sailing race enhances the feeling of fatigue, and decreases short-term memory performance. These detrimental consequences are reduced by a high-protein diet with BCAA.

Creatine has no harmful effects in football players

Br J Sports Med. 2008 Sep;42(9):731-5.
Creatine supplementation does not affect clinical health markers in football players. Cancela P, Ohanian C, Cuitiño E, Hackney AC. Lic. Biochemistry, Facultad de Ciencias, Universidad de la República, Uruguay. cohanian@netgate.com.uy

PURPOSE: To study the effects of 8-week creatine monohydrate (CrM) supplementation on blood and urinary clinical health markers in football players. METHODS: 14 football players were randomly assigned in a double-blinded fashion to Cre (n = 7) or Pla (n = 7) group. The Cre group ingested 15 g/day of CrM for 7 days and 3 g/day for the remaining 49 days, whereas the Pla group ingested maltodextrin following the same protocol. Football-specific training was performed during the study. Total body mass was determined and blood and urine samples were analysed for metabolic, hepatic, renal and muscular function markers, before and after supplementation. RESULTS: A gain of total body mass was observed after CrM intake, but not with placebo. Blood and urinary markers remained within normal reference values. There were no significant changes in renal and hepatic markers after CrM intake. However, total creatine kinase (CK) activity significantly increased, and uric acid level tended to decrease after CrM use. Likewise, serum glucose decreased in the Cre group following supplementation. No significant differences in urine parameters were found in either group after supplementation. CONCLUSIONS: 8 weeks of CrM supplementation had no negative effects on blood and urinary clinical health markers in football players. Properties of CrM may, however, be associated with an increase in CK activity, improving the efficiency for ATP resynthesis, a phenomenon indirectly confirmed by the decreasing tendency in uric acid concentration. Furthermore, CrM seems to slightly influence glucoregulation in trained subjects.

Top 10 Most Accessed Articles in 2008 for the JISSN

1. Accesses 10592	Research article Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males Dan Rohle, Colin Wilborn, Lem Taylor, Chris Mulligan, Richard Kreider, Darryn Willoughby Journal of the International Society of Sports Nutrition 2007, 4:13 (19 October 2007) [Abstract] [Full Text] [PDF] [PubMed] [Related articles]
2. Accesses 9098	Review International Society of Sports Nutrition position stand: Nutrient timing Chad Kerksick, Travis Harvey, Jeff Stout, Bill Campbell, Colin Wilborn, Richard Kreider, Doug Kalman, Tim Ziegenfuss, Hector Lopez, Jamie Landis, John L Ivy, Jose Antonio Journal of the International Society of Sports Nutrition 2008, 5:17 (3 October 2008) [Abstract] [Full Text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]
3. Accesses 8778	Commentary International Society of Sports Nutrition position stand: creatine supplementation and exercise Thomas W Buford, Richard B Kreider, Jeffrey R Stout, Mike Greenwood, Bill Campbell, Marie Spano, Tim Ziegenfuss, Hector Lopez, Jamie Landis, Jose Antonio Journal of the International Society of Sports Nutrition 2007, 4:6 (30 August 2007) [Abstract] [Full Text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]
4. Accesses 8714	Poster presentation Effect of a combination dietary supplement product (Bounce-Back™) on the signs and symptoms of delayed onset muscle soreness after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study Jay Udani, Betsy Singh, Elizabeth Sandoval Journal of the International Society of Sports Nutrition 2008, 5(Suppl 1):P24 (17 September 2008) [Abstract] [Full text] [PDF]
5. Accesses 8121	Commentary International Society of Sports Nutrition position stand: protein and exercise Bill Campbell, Richard B Kreider, Tim Ziegenfuss, Paul La Bounty, Mike Roberts, Darren Burke, Jamie Landis, Hector Lopez, Jose Antonio Journal of the International Society of Sports Nutrition 2007, 4:8 (26 September 2007) [Abstract] [Full Text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]
6. Accesses 6598	Research article Fat intake and injury in female runners Kristen E Gerlach, Harold W Burton, Joan M Dorn, John J Leddy, Peter J Horvath Journal of the International Society of Sports Nutrition 2008, 5:1 (3 January 2008) [Abstract] [Full Text] [PDF] [PubMed] [Related articles]
7. Accesses 6264	Research article Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals Matthew Cooke, Mike Iosia, Thomas Buford, Brian Shelmadine, Geoffrey Hudson, Chad Kerksick, Christopher Rasmussen, Mike Greenwood, Brian Leutholtz, Darryn Willoughby, Richard Kreider Journal of the International Society of Sports Nutrition 2008, 5:8 (4 March 2008) [Abstract] [Full Text] [PDF] [PubMed] [Related articles]
8. Accesses 6194	Review ISSN Exercise & Sport Nutrition Review: Research & Recommendations Richard B Kreider, Anthony L Almada, Jose Antonio, Craig Broeder, Conrad Earnest, Mike Greenwood, Thomas Incledon, Douglas S Kalman, Susan M Kleiner, Brian Leutholtz, Lonnie M Lowery, Ron Mendel, Jeffrey R Stout, Darryn S Willoughby, Tim N Ziegenfuss Journal of the International Society of Sports Nutrition 2004, 1:1-44 (10 May 2004) [Abstract] [Full Text] [PDF]
9. Accesses 6080	Research article Effect of carbohydrate-protein supplement timing on acute exercise-induced muscle damage James P White, Jacob M Wilson, Krista G Austin, Beau K Greer, Noah St John, Lynn B Panton Journal of the International Society of Sports Nutrition 2008, 5:5 (19 February 2008) [Abstract] [Full Text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]
10. Accesses 5993	Research article The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise Ralf Jäger, Jan Metzger, Karin Lautmann, Vladimir Shushakov, Martin Purpura, Kurt-Reiner Geiss, Norbert Maassen Journal of the International Society of Sports Nutrition 2008, 5:4 (13 February 2008) [Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Chocolate, wine and tea improve brain performance

Chocolate, wine and tea improve brain performance
Published on 22 December 2008, 09:25 Last Update: 22 hour(s) ago by Insciences

Wine, chocolate and tea can enhance cognitive performance, Oxford researchers found
All that chocolate might actually help finish the bumper Christmas crossword over the seasonal period. According to Oxford researchers working with colleagues in Norway, chocolate, wine and tea enhance cognitive performance.
The team from Oxford’s Department of Physiology, Anatomy and Genetics and Norway examined the relation between cognitive performance and the intake of three common foodstuffs that contain flavonoids (chocolate, wine, and tea) in 2,031 older people (aged between 70 and 74).
Participants filled in information about their habitual food intake and underwent a battery of cognitive tests.Those who consumed chocolate, wine, or tea had significantly better mean test scores and lower prevalence of poor cognitive performance than those who did not. The team reported their findings in the Journal of Nutrition.
The role of micronutrients in age-related cognitive decline is being increasingly studied. Fruits and beverages such as tea, red wine, cocoa, and coffee are major dietary sources of polyphenols, micronutrients found in plant-derived foods. The largest subclass of dietary polyphenols is flavonoids, and it has been reported in the past that those who consume lots of flavonoids have a lower incidence of dementia.
The latest findings seem to support the theory, although the researchers caution that more research would be needed to prove that it was flavonoids, rather than some other aspect of the foods studied, that made the difference.The effect was most pronounced for wine.
However, say the researchers, those overdoing it at Christmas should note that while moderate alcohol consumption is associated with better cognitive function and reduced risk of Alzheimer’s disease and dementia, heavy alcohol intake could be one of many causes of dementia – as well as a host of other health problems.
Contact : Maria Coyle, maria.coyle@admin.ox.ac.ukSource: University of Oxford